Vitamin E Oil: Gold-Standard Antioxidant for Lipid Protection & Skin Barrier Support

Basic Information

• INCI: Tocopherol (Natural), Tocopheryl Acetate (Stable Ester)

• CAS No.: 59-02-9 (α-Tocopherol), 7695-91-2 (Acetate)

• Molecular Formula: C₂₉H₅₀O₂

• Molecular Weight: 430.7 g/mol

• Appearance: Clear viscous amber oil

• Solubility:

  • Oil-soluble (1:1 in jojoba oil)

  • Water-insoluble (requires emulsification)

• Density: 0.95 g/cm³

• Certifications: Non-GMO, Ecocert, ISO 16128

Description: Multi-Target Lipid Defender

Natural Vitamin E Oil (d-α-Tocopherol) provides 360° protection against lipid peroxidation through:

• Chain-breaking antioxidant: Neutralizes 1 free radical every 2.5μs

• Lipid bilayer integration: Distributes in stratum corneum (3.2μg/cm²)

• UVB radiation absorption: 290-320 nm range

• Stability enhancement: Extends formula shelf-life by 18-24 months

Clinically proven to reduce TEWL by 41% while increasing ceramide levels 2.3x.

Scientific Benefits

① Quadruple Antioxidant Action

• Peroxyl radical scavenger (k=2×10⁶ M⁻¹s⁻¹)

• Regenerates oxidized Vitamin C

• Chelates iron (Fe³+ binding capacity: 0.89 mol/mol)

• Inhibits 8-OHdG formation (DNA protection)

② Barrier Reinforcement

• Increases lamellar body secretion by 57%

• Accelerates lipid synthesis (PPAR-α activation)

• Reduces soap-induced barrier damage

③ Anti-Aging Effects

• Inhibits MMP-1 collagenase (IC50=12μM)

• Boosts elastin fiber density by 29%

• Improves SC hydration (capacitance +38%)

④ Anti-Inflammatory Properties

• Reduces PGE2 production by 64%

• Suppresses NF-κB activation

• Soothes UV-induced erythema

⑤ Formulation Benefits

• Natural preservative booster

• Prevents rancidity in oil blends

• Enhances SPF efficacy (up to 20%)

Application Guidelines

➀ Antioxidant Skincare

• Vitamin C+E serums (0.5-5%)

• Sunscreen oils & after-sun care

• Anti-pollution day creams

➁ Age-Defying Formulas

• Retinol stabilization complexes

• Neck firming oils

• Eye contour serums

➂ Barrier Repair Therapies

• Eczema creams

• Post-procedure recovery balms

• Tattoo aftercare ointments

➃ Hair & Scalp Care

• Hot oil treatments

• Split end repair serums

• Scalp antioxidant tonics

➄ Specialty Products

• Cuticle oils

• Stretch mark prevention blends

• Massage oils with anti-aging benefits

  
  

Technical Specifications

• Natural vs Synthetic:

  • d-α-Tocopherol (RRR- form): Bioactive

  • dl-α-Tocopherol (All-rac-): 73% activity

• Recommended Usage: 0.1-5%

• Storage: 4-25°C under nitrogen blanket

• Oxidation Protection:

  • Add 0.1% rosemary extract

  • Avoid copper containers

Clinical Validation

• 24-Week Study (2% in emulsion):

  • -52% lipid peroxide levels

  • +31% skin smoothness

  • 89% reduction in dryness

  • No comedogenicity (rabbit ear test)

Synergistic Combinations