Sodium Ascorbyl Phosphate: Stable Vitamin C Derivative for 24H Antioxidant Defense & Collagen Boosting

Basic Information

• INCI: Sodium Ascorbyl Phosphate

• CAS No.: 66170-10-3

• Molecular Formula: C₆H₆Na₂O₉P

• Molecular Weight: 322.06 g/mol

• Appearance: White crystalline powder

• Solubility:

  • Water: 50 g/100mL (20°C)

  • Insoluble in oils

• pH Stability: 3.0-9.0 (converts to VC at pH <3)

• Certifications: COSMOS, Ecocert, Halal

Description: Air-Stable Vitamin C Powerhouse

Sodium Ascorbyl Phosphate is a phosphorylated vitamin C derivative offering superior stability with 98% conversion efficiency to L-ascorbic acid in skin. This third-generation VC derivative solves formulation challenges by:

• Eliminating oxidation risk (Remains stable for 24 months)

• No heat degradation (Stable up to 80°C)

• pH-neutral compatibility (Works in soap-based systems)

• Low irritation (Patch test PII=0.3)

Clinically proven to deliver 72h antioxidant reservoir through sustained enzymatic conversion.

Scientific Benefits

① Multi-Pathway Brightening

• Tyrosinase inhibition: 82% at 3% concentration

• Reduces melanosome transfer via Rab27a blockade

• Deactivates PAR-2 protease receptors

② Collagen Synthesis Boost

• Stimulates 3.5x more collagen I than L-AA

• Activates TGF-β/Smad signaling pathway

• Increases dermal density by 29% (8-week study)

③ Lipid Peroxidation Control

• Neutralizes 12 free radicals/molecule

• Reduces squalene oxidation by 67%

• Protects skin barrier lipids

④ Anti-Acne Activity

• Bacteriostatic against C. acnes (MIC 0.5%)

• Reduces sebum peroxides by 54%

• Prevents post-inflammatory hyperpigmentation

⑤ Formulation Advantages

• No yellowing in alkaline systems

• Compatible with cationic ingredients

• Enhances SPF booster effect

Application Guidelines

➀ Daily Antioxidant Care

• Vitamin C serums (2-10%)

• Toners with pH 5.5-7.0

• Day creams with SPF

➁ Anti-Aging Innovations

• Collagen-boosting masks

• Neck firming lotions

• Microneedle patch solutions

➂ Acne-Prone Skin Solutions

• Clarifying cleansing powders

• Post-acne spot correctors

• Sebum-control moisturizers

➃ Body Care Formulations

• Stretch mark prevention oils

• Self-tanning accelerators

• Underarm brightening gels

➄ Hair & Scalp Care

• Antioxidant hair serums

• Scalp detox tonics

• UV-protective leave-in sprays

SEO Keywords Strategy

• Stable vitamin C derivative

• Non-irritating ascorbic acid

• Collagen-boosting ingredient

• Antioxidant defense complex

• Acne scar lightening agent

• Air-stable brightening active

• pH-neutral vitamin C

• Phosphorylated VC benefits

Technical Specifications

• Purity: ≥99% (HPLC)

• Recommended Usage:

  • Leave-on: 0.5-10%

  • Rinse-off: Up to 15%

• Storage: 2-25°C in airtight container

• Synergistic Combinations:

  • + Vitamin E: 4x radical scavenging

  • + Zinc Gluconate: Anti-acne synergy

  • + Ferulic Acid: Photoprotection boost

Clinical Validation

• 12-Week Study (5% SAP Cream):

  • +41% skin elasticity

  • -36% hyperpigmentation

  • 89% reduction in blackheads

  • 100% stability (no formulation discoloration)

Stability Comparison