Kojic Acid Dipalmitate :

Oil-Soluble Brightening Powerhouse with Enhanced Stability

Basic Information

• INCI Name: Kojic Acid Dipalmitate

• CAS No.: 79725-98-7

• Chemical Formula: C₃₈H₆₆O₆

• Molecular Weight: 643.0 g/mol

• Appearance: White to off-white crystalline powder

• Solubility:

  • Oil-soluble (5% in caprylic/capric triglyceride)

  • Insoluble in water

• Melting Point: 58-62°C

• Stability: pH 3.0-8.0, heat stable ≤160°C

Description: Next-Gen Melanin Control

Kojic Acid Dipalmitate is a lipophilic derivative of kojic acid with 3x enhanced stability and oil-compatible properties. This innovative esterification technology overcomes traditional kojic acid limitations by:

• Eliminating sensitivity to pH/oxidation

• Enabling lipid-phase formulations

• Providing sustained release (8-12h activity)

• Reducing irritation potential (PII=0.2 vs 1.8 for kojic acid)

Clinically proven to inhibit tyrosinase 23% more effectively than arbutin at 1% concentration.

Key Functional Advantages

① Advanced Melanogenesis Control

• Dual inhibition mechanism:

  • Chelates copper in tyrosinase active site

  • Suppresses MITF transcription

• IC50 for tyrosinase: 8.5 μM (vs 25 μM for kojic acid)

• Reduces UV-induced pigmentation by 62%

② Antioxidant & Anti-Glycation

• ORAC Value: 12,000 μmol TE/g

• Inhibits AGEs formation by 41%

• Protects collagen from sugar damage

③ Formulation Versatility

• Stable in anhydrous systems (oils, silicones)

• Compatible with high-temperature processing

• pH-insensitive (3.0-8.0)

④ Synergistic Combinations

• + Vitamin C Derivatives: 2.3x brightening boost

• + Niacinamide: Reduces melanosome transfer

• + Retinol: Counteracts irritation-induced PIH

Application Guidelines

➀ High-Performance Whitening

• Vitamin C serums (1-3%)

• Retinol night creams (0.5-1%)

• Spot-correction essences

➁ Sun Care Innovations

• SPF50+ face sunscreens

• Post-sun recovery balms

• BB creams with UV protection

➂ Body Care Solutions

• Underarm brightening gels

• Knee/elbow darkening creams

• Pregnancy line prevention oils

➃ Men's Grooming

• Razor bump prevention aftershaves

• Beard lightening serums

• Post-acne mark correctors

➄ Hair Care Applications

• Scalp pigment-balancing tonics

• Color-treated hair protectants

• Gray hair yellowing inhibitors

Technical Specifications

• Recommended Usage: 0.5-3%

• Storage: 2-25°C in airtight container

• Regulatory Status:

  • China IICID Approved

  • EU Cosmetic Regulation Compliant

  • Japan PAL compliant

  • Not restricted in ASEAN

Clinical Validation

• 28-Day Trial (2% in emulsion):

  • 78% subjects showed even tone

  • ΔITA° increase from 35 to 48

  • 92% reported no irritation

Stability Comparison