AcHA: Dual-Soluble Hyaluronic Acid with 24H Multi-Layer Hydration & Barrier Intelligence

Basic Information

• INCI: Sodium Acetylated Hyaluronate

• CAS No.: 9067-32-7 (modified)

• Molecular Weight: 5-50 kDa (Customizable)

• Lipid Solubility: LogP = -0.37 → +1.02 (Acetylation Enhanced)

• Water Solubility: 98% (w/w, 25°C)

• Viscosity: 200-800 mPa·s (1% Solution)

• Certifications: Halal, Kosher, RSPO Mass Balance

Description: Amphiphilic Hydration Revolution

AcHA combines dual-phase solubility through advanced esterification:

• Acetyl groups enable stratum corneum penetration (20μm depth)

• Negative charge retains dermal moisture reservoir

• Self-assembling micelles (8-15nm) for time-release hydration

Proven 18h continuous hydration via 3D skin model, outperforming standard HA by 6x.

Scientific Benefits

① Intelligent Moisture Allocation

• Surface: Forms 2μm occlusive film (TEWL↓61%)

• Mid-layer: Binds 9 water molecules/unit

• Deep: Stimulates aquaporin-3 (+37% expression)

② Multi-Path Anti-Aging

• Inhibits MMP-2/9 collagenases (IC50=28μM)

• Boosts type I collagen 2.3x (fibroblast study)

• Reduces IL-6 inflammation markers by 44%

③ Lipid Barrier Optimization

• Increases ceramide EOP by 29%

• Enhances NMF production (+19% PCA)

• Repairs acid mantle in 8h (pH 4.5→5.2)

④ Advanced Delivery System

• 78% transcellular penetration efficiency

• Carries actives 5x molecular weight

• Stable with vitamin C (pH 3.5-5.5)

⑤ Sensory Enhancement

• Silky afterfeel (friction coefficient 0.15)

• Reduces formulation tackiness by 67%

• Compatible with silicone oils

Application Guidelines

➀ Next-Gen Skincare

• 24H moisturizing serums (0.1-0.8%)

• Anti-aging ampoules (0.5-1.2%)

• Barrier repair creams (0.3-1.5%)

➁ Sun Care Systems

• Water-resistant sunscreens (0.2-0.6%)

• Post-UV recovery gels (0.4-1%)

• Blue light protection emulsions

➂ Color Cosmetic Tech

• Long-wear foundation (0.1-0.3%)

• Transfer-proof lipstick

• Eyelash growth serums

➃ Medical Aesthetics

• Microneedling solutions (0.8-2%)

• Laser aftercare (1-3%)

• Burn healing ointments

➄ Men's Grooming

• Beard softener balms

• Anti-irritation shave gels

• Scalp hydrating tonics

Technical Specifications

• Recommended Usage:

  • Leave-on: 0.05-2%

  • Rinse-off: 0.1-5%

• pH Compatibility: 3.5-7.0

• Synergistic Partners:

  • + Ceramides: Barrier synergy

  • + Niacinamide: Moisture barrier

  • + Retinol: Irritation mitigation

• Avoid:

  • High ionic strength (>0.5M)

  • Alkaline conditions (pH >8)

Clinical Validation

• 28-Day RCT (0.5% AcHA Serum):

  • +152% hydration (Corneometer®)

  • -59% TEWL

  • 94% improved elasticity

  • 0% irritation incidence