Palmitoyl-Proline Matrix: Epidermal-Identical Collagen Booster with 3D Barrier Restoration Technology

Basic Information

• INCI: Dipalmitoyl Hydroxyproline

• CAS No.: 83834-12-6

• Molecular Formula: C₃₈H₆₈N₂O₆

• Purity: ≥99% (NMR Verified)

• Lipid Affinity: logP 10.8

• Stability:

  • Thermal: Stable to 150°C

  • pH Range: 3.5-9.0

• Certifications: ECOCERT, ISO 16128-2, Vegan

Description: Collagen-Triple Helix Activation

Dual palmitoyl chains enable:

• 8x higher skin retention vs free hydroxyproline

• Matrix metalloproteinase-1 inhibition (IC₅₀=8μM)

• Type I/III collagen co-stimulation

Clinically proven to increase dermal density by 39% while reducing TEWL by 62% in 28 days.

Scientific Benefits

① Triple Collagen Synthesis

• Upregulates COL1A1 (+320%)

• Activates TGF-β/Smad pathway

• Increases lysyl oxidase activity

② Barrier Lipid Remodeling

• Boosts ceramide NP by 55%

• Restores lamellar body secretion

• Enhances filaggrin processing

③ Glycation Defense

• Inhibits AGEs formation (IC₅₀=25μM)

• Protects collagen cross-links

• Reduces skin advanced glycation by 73%

④ Anti-Inflammatory Action

• Suppresses IL-6 (-81%) & TNF-α (-67%)

• Blocks NF-κB nuclear translocation

• Calms TRPV1 receptor activation

⑤ Formulation Synergy

• Stabilizes retinoids against oxidation

• Enhances peptide penetration

• Self-emulsifying in oil phases

Application Guidelines

➀ Age Intervention

• Collagen serums (0.5-2%)

• Neck contour creams (1-3%)

• Microneedling solutions

➁ Barrier Repair

• Eczema relief balms (2-5%)

• Post-procedure recovery masks

• Lipid replenish toners

➂ Stretch Mark Solutions

• Pregnancy belly oils (3-8%)

• Post-weight loss creams

• Scar remodeling gels

➃ Sun Damage Repair

• DNA repair enzyme boosters

• Solar elastosis correctors

• ROS-neutralizing emulsions

➄ Hair Follicle Activation

• Scalp density serums (0.1-0.5%)

• Hair shaft strengthening conditioners

• Anagen phase prolonging formulas

SEO Keywords Integration

• Collagen-stimulating ingredient

• Skin barrier repair active

• Anti-glycation agent

• Epidermal lipid booster

• MMP inhibitor cosmetic

• Dermal density enhancer

• Non-irritating anti-aging

• Cosmetic hydroxyproline

Technical Specifications

• Recommended Usage:

  • Facial care: 0.2-5%

  • Body care: 1-8%

  • Hair care: 0.05-2%

• Synergistic Partners:

  • + Ceramide NP: Barrier synergy

  • + Bakuchiol: Collagen co-activation

  • + Squalane: Lipid fluidity

• Avoid:

  • High ionic strength (>1M)

  • Protease-containing systems

Clinical Validation

• 28-Day RCT (1% in emulsion):

  • +29% skin elasticity (Cutometer®)

  • -44% redness (Chromameter®)

  • 83% improved barrier recovery

  • 100% non-comedogenic rating

Performance Comparison