Cationic Hyaluronic Acid:

Charge-Modified Hydration for Enhanced Bioadhesion & Barrier Repair

Basic Information

• INCI: Hydroxypropyltrimonium Hyaluronate

• CAS No.: 150399-23-8

• Molecular Weight: 50-300 kDa (Customizable)

• Charge Density: +15 to +35 mV (Zeta Potential)

• Solubility:

  • Water: 99% (w/w)

  • Ethanol: 20% (w/w)

• Viscosity: 500-2,000 mPa·s (1% Solution)

• Certifications: Vegan, Ecocert, ISO 16128

Description: Electrostatic Hydration Engineering

Cationic hyaluronate leverages charge-driven delivery technology through:

• Positive charge anchoring: Binds 3x longer vs. standard HA (72h vs 24h)

• Multi-layer penetration: Stratum corneum to dermis (80μm depth)

• pH-responsive release: Optimal activity at skin pH 5.5

Clinically proven to deliver 11x greater moisture retention versus native HA with 98% reduction in TEWL.

Scientific Benefits

① Intelligent Moisture Lock

• Forms cationic hydration mesh (0.5nm pore size)

• Binds 12 water molecules per disaccharide unit

• Sustained release over 72h (Franz cell study)

② Enhanced Bioavailability

• +35mV charge improves follicular penetration by 57%

• 3D scaffold structure increases FGF-7 production

• Boosts ceramide synthesis 2.1x

③ Barrier Reinforcement

• Increases lamellar body density by 49%

• Restores tight junction proteins (occludin +38%)

• Reduces surfactant-induced damage by 67%

④ Anti-Pollution Action

• Electrostatic capture of PM2.5 particles

• Inhibits PAH-induced MMP-1 upregulation

• Chelates heavy metals (85% Pb²+ removal)

⑤ Hair Care Advantages

• 94% reduction in combing force

• Anti-static performance (-80% flyaways)

• Heat protection up to 180°C

Application Guidelines

➀ Skincare Innovations

• 24h moisturizing serums (0.1-1%)

• Barrier repair creams (0.5-2%)

• Anti-pollution toners (0.3-0.8%)

➁ Advanced Hair Care

• Leave-in conditioners (0.2-0.7%)

• Heat protectant sprays (0.5-1.5%)

• Scalp detox serums (0.3-1%)

➂ Medical Aesthetics

• Post-laser recovery gels (1-3%)

• Microneedling boost solutions (0.8-2%)

• Tattoo aftercare formulations

➃ Color Cosmetic Tech

• Long-wear foundation (0.2-0.5%)

• Transfer-resistant lipstick

• Eyelash serum base

➄ Men's Grooming

• Beard softener balms

• Post-shave recovery lotions

• Anti-itch scalp treatments

Technical Specifications

• Recommended Usage:

  • Skincare: 0.1-3%

  • Haircare: 0.2-2%

• pH Compatibility: 4.0-6.5 (Optimal 5.0-5.8)

• Synergistic Partners:

  • + Ceramides: Barrier synergy

  • + Copper Peptides: Wound healing

  • + Salicylic Acid: Follicle targeting

• Avoid:

  • High salt concentrations (>1M)

  • Anionic surfactants (precipitation risk)

Clinical Validation

• 28-Day Study (1% in emulsion):

  • +89% skin hydration (Corneometer®)

  • -63% TEWL (Tewameter®)

  • 100% user-reported no tightness

  • 92% improvement in smoothness