Oil-Soluble Vitamin C Derivative: 360° Antioxidant Matrix with Enhanced Epidermal Delivery & Photoaging Defense

Basic Information

• INCI: Ascorbyl Tetraisopalmitate

• CAS No.: 183476-82-6

• Molecular Formula: C₃₃H₅₈O₈

• Purity: ≥98% (HPLC)

• Lipophilicity: logP 8.2 (Octanol/water)

• Stability:

  • Oxygen stability: 24M at 40°C

  • pH Range: 3.0-8.0

• Certifications: COSMOS, ISO 16128, Halal

Description: Quadruple Palmitate Innovation

The 4-isopalmitoyl ester structure enables:

• 8x greater skin penetration vs L-ascorbic acid

• pH-independent activity (vs pH-sensitive derivatives)

• Self-antioxidizing system regenerates α-tocopherol

Clinically proven to reduce UV-induced ROS by 91% while maintaining 95% potency after 12M storage.

Scientific Benefits

① 3D Collagen Synthesis

• Increases procollagen I mRNA (+228%)

• Inhibits MMP-1 (IC₅₀=12μM)

• Enhances LOXL2 enzyme activity

② Melanocyte Regulation

• Reduces tyrosinase activity 63%

• Blocks α-MSH binding to MC1R

• Inhibits PAR-2 mediated transfer

③ Lipid Peroxidation Shield

• Neutralizes 14 types of lipid radicals

• Protects squalene from oxidation (98% retention)

• Maintains stratum corneum integrity

④ Sebum Quality Control

• Reduces comedogenic oleic acid by 44%

• Increases antimicrobial sapienic acid

• Balances scalp microbiome

⑤ Formulation Advantages

• Heat-stable up to 85°C

• No chelator requirement

• Compatible with all emulsion types

Application Guidelines

➀ Age-Defying Systems

• Anti-aging serums (1-3%)

• Neck firming creams (0.5-2%)

• Microneedle ampoules

➁ Hyperpigmentation Solutions

• Spot correctors (2-5%)

• Post-peel recovery balms

• Melasma prevention SPF

➂ Sun Care Synergy

• Antioxidant SPF boosters (0.5-1.5%)

• Post-UV repair masks

• Infrared radiation protectants

➃ Hair & Scalp Care

• Scalp antioxidant tonics (0.2-1%)

• UV-protective hair serums

• Gray hair prevention formulas

➄ Advanced Delivery

• Liposome encapsulation

• Oleogel carriers

• Pickering emulsion stabilization

Technical Specifications

• Recommended Usage:

  • Facial care: 0.2-5%

  • Body care: 0.5-3%

  • Hair care: 0.1-2%

• Synergistic Partners:

  • + Vitamin E: Radical recycling

  • + Ferulic Acid: Stability enhancement

  • + Niacinamide: Tone uniformity

• Avoid:

  • High pH (>8.5) systems

  • Ionic surfactants (>15%)

Clinical Validation

• 12-Week RCT (2% Serum Formula):

  • +37% skin evenness (VISIA®)

  • -29% wrinkle volume

  • 91% antioxidant activity retention

  • 0% irritation reported

Performance Comparison