4D Sodium Hyaluronate Hyaluronic acid powder

4D Sodium Hyaluronate

4D Sodium Hyaluronate: Multi-Layer Hydration Matrix for Next-Gen Skincare


Basic Information


  • INCI: Sodium Hyaluronate (Multi-Molecular Weight)

  • CAS No.: 9067-32-7

  • Molecular Weight Spectrum:

    • Macro-HA (1,500-1,800 kDa): Surface film-forming

    • Meso-HA (800-1,000 kDa): Epidermal reservoir

    • Micro-HA (50-100 kDa): Dermal delivery

    • Nano-HA (5-10 kDa): Cellular signaling

  • Purity: ≥98% (HPLC)

  • Appearance: White hygroscopic powder

  • Solubility: Instant cold-water soluble

  • Certifications: ISO 16128, COSMOS, Vegan




Description: Quadruple-Action Hydration Architecture


4D Sodium Hyaluronate combines four precision-engineered molecular weights to create a time-released hydration system:


Molecular Weight

Penetration Depth

Key Function

1,800 kDa

Stratum Corneum

Forms breathable moisture shield

1,000 kDa

Granular Layer

Creates intercellular reservoir

100 kDa

Papillary Dermis

Stimulates aquaporin-3

10 kDa

Reticular Dermis

Triggers CD44 receptor repair


Clinically proven to deliver 72-hour hydration through intelligent moisture distribution.




Scientific Benefits


① Multi-Dimensional Hydration


  • 800% water-binding capacity (vs. standard HA)

  • 4-layer moisture matrix prevents TEWL

  • Adapts to humidity changes (10-90% RH)


② Anti-Glycation Barrier


  • Reduces AGEs formation by 62%

  • Protects collagen VII anchoring fibers


③ Wound Healing Acceleration


  • Increases fibroblast migration by 3.1x

  • Enhances post-procedure recovery


④ Signal Transduction


  • Nano-HA activates TLR-4 receptors

  • Upregulates natural HA synthesis


⑤ Formulation Enhancer


  • Reduces stickiness in serums

  • Stabilizes vitamin C (pH 3.5-6.5)

  • Compatible with electrolytes




Recommended Applications


➀ Premium Skincare Systems


  • Multi-phase hydration serums (0.1-2%)

  • Bio-fermented essence formulations

  • Cryo-globe applicator products


➁ Medical Aesthetics


  • Microneedling recovery solutions

  • Laser post-care gels

  • Filler-boosting cocktails


➂ Barrier Repair


  • Eczema/psoriasis creams

  • Post-retinol recovery balms

  • Tattoo aftercare lotions


➃ Menopausal Skin Care


  • Hormonal dryness treatments

  • Collagen-plumping masks

  • Neck & décolletage regimens


➄ Ocular Formulations


  • Dry eye relief serums

  • Eyelid hydration patches

  • Lash growth enhancers